The Chicago Stroke Trials Consortium (CSTC) led by the RCC at The University of Chicago is a collaborative network of 13 centers in the Chicago metropolitan area and southeastern Wisconsin area. The RCC aims to combine resources, diverse faculty with stroke expertise, and access to a multi-ethnic population of stroke patients from a combined geographic referral base encompassing almost 10 million people. The amassed investigators have backgrounds in all aspects of stroke research and leadership roles. The CSTC aims to provide cutting-edge stroke treatments to a diverse patient population, provide consolidated multi-disciplinary and multi-institutional expertise and leadership for Network trials, and ensure mentoring for the next generation of stroke investigators.